Evaluation of Volatility of Bendamustine Using Solid Phase Extraction-Type Extraction Device
نویسندگان
چکیده
Bendamustine (BD), a volatile anti-cancer drug in Japan, was quantitatively evaluated using solid phase extraction (SPE)-type device designed for the adsorption of gaseous semi-volatile organic compounds. First, stability BD tested various conditions, including solvent, temperature, and contact with oxygen. Then, standard solution spiked on filter paper, SPE-type connected to downstream. The were then used collect clean air. actual volatility determined high-performance liquid chromatography. Even after 24 h air sampling at 7 L/min (10,080 L), results demonstrated that evaporation not confirmed. Furthermore, confirmed 7,000 L volume heated 50°C. properties n-alkanes C26H54, C28H58, C30H62 these conditions compared. show is room temperature.
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ژورنال
عنوان ژورنال: Chromatography
سال: 2022
ISSN: ['1342-8284', '1348-3315']
DOI: https://doi.org/10.15583/jpchrom.2022.003